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项目介绍 |
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项目名称：高原低氧等环境因素损伤适应机理与干预措施
项目编号：2006CB504100
项目领域：人口与健康
第一承担单位：中国人民解放军军事医学科学院基础医学研究所
开始日期：2006-09-01
预计完成日期：2011-08-31
概述：
由于我国特定的地理、地貌决定，高原低氧等环境因素的危害非常严重。有关损伤适应机理和防护措施的研究，不仅有利于那里自然资源的开发利用，而且有助于管理与开发这些少数民族聚集的边陲要地，有着深远的经济和政治意义。由于氧的利用和调节是高等生命生存的基本条件，有关研究将有助于深化对生命本质的认识。由于低氧也是许多重大疾病发生发展中的基本病理生理改变，有关成果可以为临床相关重大疾病的研究提供思路并服务于航天、航空、航海、极地、水下医学与运动医学等相关领域。
我们在低氧损伤的机制和防护方面已经有了大量的工作，而在相关适应发生发展的规律与机理有新的发现和生长点。因此，本项目将以低氧损伤适应机制及其相关干预措施为主要研究方向。根据目前国际的研究热点和我们以往工作的创新性发现，提出的关键科学问题是：“低氧适应的多途径协同诱导与多方向转归的细胞分子机制。
根据这一科学问题，我们集中了国内高原医学、环境医学、应用生理学以及相关基础研究的优势单位；在以往几十年的研究工作和特色资源的采集的基础上开展研究。总体研究方案是从低氧信号感知、传导相关的信号分子和有关基因入手，探讨低氧适应的发生机制，寻找低氧敏感生物标记物；从损伤－适应相互转化、交叉适应和适应的新形式入手，探讨低氧适应的转归机制，寻找抗低氧损伤的内、外源性物质。在这些工作的基础上研发抗损伤、促适应的干预措施。达到建立预警－预防－诊断－治疗干预体系的目的。
As “would fastigium” locates in China, we should pay special attention to study of injury and adaptiong of hypoxia. Which is very important for the economic and social development of both altiplano area and whole country. Oxigen plays critical roles in life existence and evolution, while hypoxia plays important roles in pathological mechanism in many clinic disease. As a result, the study of hypoxia also give us a window to look into intrinsical corner of life and disease..
On the solid background of the study of altiplano medicine and physiology, we will introduce new theories and techniques of cellular and molecular biology, and combine these with our unusual biological resources of altiplano to carry out this project. Our stradegy is to pay more attention to hypoxia adaption in order to discover a century’s mystery: “who can go to high and how can adapt high”, and especially to its mechanism, its individual difference and its promotive factors. According to cut edging development of this field, we propose the scientific issue of this project as “Cellular and molecular mechnism for the multi-way development and turnover of hypoxic adaption ”
Top institutions in the filde of plateau medicin, environmental medicin and apply physiology in China were united for the project with study experience and natural resources for nearly half centry. The proposal will began from hypoxic signal sens and transduction, into relative genes SNP and expression and other molecular events underline hypoxic adaption. Main purpose of the study is to discover bio-markers for hypoxic sensitiveness and materials against hypoxic injury. It will be predicted that intervetional study may be raised from these study and turn to new practical methods.
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